Are we facing a dementia time-bomb, thanks to record numbers of Britons taking cocaine as a recreational drug?
As cocaine use among middle-aged and older Britons hits record levels, experts are warning of a wave of coke-driven dementia cases, thanks to the damage that the drug can wreak on our大脑。
警告警告说，这种损害可能在最小化药物的人中会发生这种损害。 class =“ mol-para-with-font”>英国成年人现在正在消耗创纪录的可卡因可卡因盐酸盐，欧洲化学家首先学会了在1860年代工业化的苦白水晶。
British adults are now consuming record amounts of cocaine
And the highest drug-death rate is among men in ‘Generation X’, particularly those aged 40-49, according to the Office对于国家统计（ONS）。
可卡因痴呆症危险的早期迹象发生在2021年，当时葡萄牙和巴西调查人员的财团警告说，即使在某些情况下，即使在一次杂志上都可能会使用少量药物进行大脑变化。 Neuroscience, discovered that in laboratory mice, a single episode showed up in post-mortem examination of their brains as ‘alterations in the prefrontal cortex and hippocampus’.
Numerous studies have implicated damage to these brain areas in Alzheimer’s disease and other forms of dementia.
The例如，海马参与形成新的记忆，而前额叶皮层在调节记忆，注意力和自我控制中起着重要作用。
这种早期损害似乎是'不可避免的'，而小鼠在他们的行为中没有明显的变化，他们的行为没有明显的变化，他们的行为The researchers warned that recreational ‘light’ use is wrongly considered to be harmless, ‘in part, due to the belief that exposure to low doses of cocaine carries no brain damage risk’.
Meanwhile, researchers at the University of Cambridge have been looking at the long-term risks for the brain, with a study in the journal Brain Communications in 2022年将183个可卡因用户的大脑与148个非用户的扫描（全部在30年代中期）进行了MRI扫描。
结果表明，结果显示了可口可乐中的'异常大脑衰减'。 What’s more, researchers found changes in the way different regions of the brain communicated with each other typical of those seen in people over 60 who are entering cognitive decline.
Previous research by the same team in 2012, in the journal Molecular Psychiatry, found the rate of age-related brain volume loss in cocaine-dependent individuals was almost twice that seen in healthy volunteers.
他们警告说，可卡因可以触发过度活跃的自噬（自噬是一种正常的，必要的细胞“清理工艺”，可以在这可能是因为可卡因使我们的脑细胞破坏。 class =“ mol-para-with-font”>在2016年国家科学院会议录中写作，他们说可卡因加速了这一过程。
'一个牢房就像一个家庭，就像一个不断产生垃圾的家庭，’ class =“ mol-para-with-font”>’自噬取出垃圾，这通常是一件好事。 src =“ https://i.dailymail.co.uk/1s/2025/07/03/03/11/99963005-14871543-image-image-image-a-3_1751537390749.jpg”除碎片的碎片外，更重要的是“扔掉”“ class =” class =“ blkborder img-share” style =“ max-width：100％“ loading =“ lazy” />
prasun guha> prasun guha> prasun guha说，可可蛋白可以触发过度活跃的自动化，以及de de de de de de de de de de de de de de de de de de de de de de debris de de de de de de de de de de de de de de debris' class =“ mol-para-with-font”>尽管所有这些令人震惊的证据，但英国目前尚无资金来充分研究可卡因对脑衰老的影响。
“ mol-para-with-font”> karen ersche，凯伦·埃斯切（Karen Ersche可卡因的使用，不幸的是，我无法获得资金继续进行这项研究。'
'我们通常在中年中会看到的中年使用者中的认知缺陷 learning.’
Professor Ersche urges NHS doctors to be on the lookout for early signs of dementia in cocaine-users who might ordinarily seem too young to be developing such problems, adding: ‘These individuals’ brains may appear older than their chronological age would suggest.’
Dementia aside, new关于可卡因对大脑的其他有效和持久影响的证据。
一项研究于今年3月发表的一项研究在美国国家毒品的科学家杂志上发表在马里兰州美国国家药品的eneuro杂志上，马里兰州发现可卡因的可卡因发现可卡因延长了大脑循环和增强型号的刺激性。自然而然的冲动行为发生率较低的大鼠发现，可卡因在大脑的中层临界系统之间损坏了联系，这会使我们冲动地期望获得回报，而“文明”的前额叶皮层可以调节社会行为，并降低了这种冲动性的社会行为。可卡因通过阻止一种称为多巴胺转运蛋白的蛋白质。 src =“ https://i.dailymail.co.uk/1s/2025/07/03/11/11/99963623-14871543-image-mimage-m-5_175151538287204.jpg”高=由于可卡因而导致的鼻中隔的完全崩溃“ class =” class =“ blkborder img-share” style =“ max-width：100％” loading =“ lazy” />
danniella westbrook，他在EastEnders的Sam Mitchell在EastEnders中玩过Sam Mitchell，他在EastEnders中扮演Sam Mitchell，遭受了< /sepender的全面折磨< / class="mol-para-with-font">This helps manage levels of the ‘feel good’ brain chemical dopamine – ensuring the brain doesn’t interpret every experience as pleasurable.
Cocaine blocks it, allowing dopamine to run wild and causing the brain to perceive all experiences as pleasurable.
Claus领导这项研究的神经科学教授洛兰德说：“当可卡因阻止多巴胺转运蛋白时，我们感官给出的所有类型的输入似乎很棒。负担得起的。’
ersche教授的确有一些希望的消息，至少是：‘我们最近显示n已经销售的药物可以帮助可卡因成瘾的患者减少冲动性。’
目前使用该药物（atomoxetine）来提高注意力和降低ADHD。 in the brain involved in controlling behaviour.
In the journal Biological Psychiatry in March this year, Professor Ersche, with colleagues in Australia and Germany, reported how the drug significantly reduced impulsivity in 28 patients who were compulsive cocaine users, and thus inhibited the risk-seeking desires that impel them to take illegal drugs.
已经在人类中批准了阿托西汀可以将其重新用于可卡因使用者的疗法。
在此效果中，这是一个 Nearly three-quarters of long-term cocaine users had some form of cardiovascular disease, according to a study in 2021 – in the report, based on MRI scans and published in the journal Cureus, the researchers added that cocaine is the main cause for drug-related emergency hospital cases在全球范围内，大多数入院都是用于心血管问题。 已知该药物对心脏组织具有毒性作用。 今年4月的罗马大学研究，在今年4月的一项研究中，在杂志的诊断中发表了30 cocainse process in 30 cocainse specation in 30 cocainse specials profes in 30 cocainse，炎症和其他危险的心脏异常，例如间质水肿 - 与心力衰竭相关的液体的积累。 许多研究还表明，可卡因可能会导致突然的，意外的心脏危机，通常在服用药物的数小时内。 died in a fatal car crash in County Tyrone last year, after suffering a heart attack while driving, which was caused by ‘excessive use of cocaine’. So-called ‘coke strokes’ – propelled by sudden drug-induced rises in blood pressure – are another commonly seen可卡因使用的结果。 症状通常比标准中风差，长期损害更严重，德克萨斯大学的神经病学家说，他们比较了45名可卡因折射患者，他们与从未服用Cocaine的105名可卡因患者与105名中风患者进行了比较。根据2010年发表在《中风》杂志上的研究。 重复的可卡因的使用会侵蚀胶水和牙齿恩酰胺的风险It can also lead to jaw pain, acidic saliva that leads to tooth decay and loss, gingivitis (gum disease) and rhinitis (a chronically blocked nose). A 2021 study in the American Journal of Dentistry by researchers at the Federal University of Santa Maria in Brazil, found habitual cocaine users are 46 per cent more likely to lose their teeth, have more frequent and severe cavities and a higher risk of gum disease. Cocaine use can cause potentially fatal gastric problems such as mesenteric ischaemia (a lack of blood flow to the small甘醇），肠道和肠穿孔的坏疽（肠道上的一个孔）。 早在2006年，米德尔塞克斯大学医院的外科医生在医学杂志上警告，医学杂志在皇家医学学会上，这种急性腹部问题可能会在一个小时和痛苦的情况下进行痛苦，最初是cocain的痛苦 - 海洋，呕吐和血腥的腹泻。 可卡因的使用也与危及生命的肠子损伤有关，以缺血性结肠炎的形式 - 肠子的血液供应被药物损害，导致大型肠子损害和炎症。症状包括腹痛，腹泻和出血。 class =“ mol-para-th-font”>医生报告说，一些完全停止使用可卡因的患者如何仍患有严重的炎症自身免疫性状况，例如血管炎持续发炎，引起了众多症状，这些症状会引起众多疼痛，疲劳和器官失败，包括STROKE
蛀牙和损失
GASTRIC PROBLEMS INCLUDING GANGRENE
“ mol-para-with-font”>“ mol-para-with-font”>“这不仅会改变这些蛋白质，而且还会使这些蛋白质变化，从而使它们受到攻击的侵害，并且会导致其自身的攻击 - 构成了自己的攻击 - 构成的侵害 - autoimmune disease.
‘COKE NOSE’
The most notoriously obvious damage caused by cocaine is catastrophic damage to the nasal septum - commonly known as ‘coke nose’, which has been publicised previously by the former EastEnders actress Danniella Westbrook兼歌手Kerry Katona。一个朋友的两个字诽谤使我震惊了我的核心