澳洲“法老王诅咒”背后的有毒真菌如何杀死癌细胞

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英国贵族卡那文(Lord Carnarvon)是最早进入塔坦卡蒙国王(King Tutankhamun)重新发现的坟墓的人之一,并看到了它的宝藏:金色战车,雪萨(Scarab法老的诅咒 - 任何打扰木乃伊坟墓的人都注定不幸。

”国王图坦韩的石岩石棺在2007年被取消,因此法老王的遗体可以转移到埃及金斯山谷的坟墓内的气候控制的玻璃盒中。”

国王图坦卡蒙国王的石头石棺在2007年被取消,因此法老王的遗体可以移至他在埃及金斯谷的墓碑中的气候控制的玻璃盒子, AP

一些科学家怀疑真正的杀手是由一种有毒的真菌感染的,这些真菌像笨拙的陷阱一样在坟墓中处于休眠状态: aspergillus flavus flavus 。 Now the fungus is again at the centre of intrigue after researchers in the US crafted the deadly spores into a compound that can kill cancer cells.

In the search for new drugs, scientists have been studying a group of natural molecules called RiPPs (ribosomally synthesised and post-translationally modified peptides).

Many of these tiny proteins have proved toxic to infectious microbes and cancer cells, which is why researchers are on the hunt for new types of RiPPs to test their medical potential.

“We often think of fungi as causing disease or food spoilage, but this is an example of them holding the key to treating diseases.”

Dr Justin Beardsley, University of悉尼

已经在细菌中发现了数千种这些分子,但只有少数来自真菌的分子,这就是为什么宾夕法尼亚大学的研究人员以 aspergillus

寻找与人类相互互动的ripp ripp的新类型的原因。然后,一些分子阻止了癌细胞的生长。

科学家随后添加了蜜蜂喂养其幼虫的脂肪分子。 The fat molecule or “lipid” helped the cancer-busting RiPPs to infiltrate leukemia cells, and together the experimental combination performed as effectively as two existing leukemia drugs.

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“Cancer cells divide uncontrollably,” said 自然化学生物学研究的高级作家Xue Gao副教授。 “这些化合物阻止了微管的形成,这对于细胞分裂至关重要。”

“

Aspergillus fungi can cause a deadly lung infection.Credit:

The molecules didn’t have an effect on breast, liver or lung cancer cells. A molecule that only interacts with a specific type of cell can但是,要制造一种有用的药物,因为

这是非常早期的研究,就分子发展成可能有一天在人中的药物的潜力而言,俗话说,俗话说的是,包括手工的

aspergillus aspergillus

aspergillus

的专家说,

估计的1000万种真菌的负载

已正式描述。说。 class =“ fryzg noprint” id =“ endofarticle”> <按钮aria-checked =“ false” aria-descred by =“ savetooltip” aria-label =“ aria-label =”保存文章,以稍后阅读class =“ lyny4” crom =“ lyny4” crom =“ prole =” switch type =“ button”> <使用xlink:href =“#icon-save”> 保存 登录 in 澳洲中文论坛热点

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